Population, Neurodevelopment and Genetics program

Daniel Keating

Daniel KeatingResearch Professor

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3302 ISR
426 Thompson St.
Ann Arbor, MI 48104




Dr. Keating’s research focuses on integrating knowledge about developmental and biodevelopmental processes, population patterns in developmental health, and social factors affecting individual and population development. Current lines of research include:

  • The Adolescent Health Risk Behavior (AHRB) Study, a new longitudinal cohort study (projected sample size of ~ 2000; funded by an R01 from NICHD) that includes self-report information on psychosocial development, risk behaviors, and perspectives on risk behaviors that have been engaged in; and neurocognitive assessments tapping executive function and risk/reward processing. This large sample will participate in 3 additional waves of data collection. In addition, about 200 of these adolescent participants (in 10th or 12th grade; half high risk takers, half average risk takers who are demographically matched) will participate in a neuroimaging assessment to test a developmental maturity mismatch hypothesis contrasting prefrontal development with arousal and reward circuitry (fMRI, DTI, and EEG/ERP).
  • International comparisons on the relationship between the SES gradient in developmental health, especially educational performance and self-reported health, and the overall performance of different countries. The next phase of research focuses on country-specific indicators of developmental opportunities, and how they relate to the country-level social gradient and mean performance.
  • Analyses of longitudinal data sets to study population outcomes of developmental health with regard to how those patterns may be explained by underlying developmental mechanisms.

A major thrust of this work has been to identify the social circumstances that have an enduring impact on developmental health, and to discover the developmental mechanisms through which those social circumstances operate. A longer term goal of this line of work is to identify the key aspects of social environments that shape developmental experiences in early childhood through the adolescent transition, in ways that can be addressed at the level of policy and practice.

Current course offerings include a graduate seminar on social disparities in developmental health, an undergraduate course in Psychology of Adolescence, and an undergraduate offering in advanced research in adolescent development.




  • Keating DP. Adolescent health risk behavior: the road ahead. J Adolesc Health. 2024;74(3):397-399. doi:10.1016/j.jadohealth.2023.12.008
  • Demidenko MI, Huntley ED, Du L,…Keating DP. Individual and community level developmental adversities: associations with marijuana and alcohol use in late-adolescents and young adults. J Youth Adolesc. 2024;53(4):799-813. doi:10.1007/s10964-023-01881-9
  • Constante K, Demidenko MI, Huntley ED, Rivas-Drake D, Keating DP, Beltz AM. Personalized neural networks underlie individual differences in ethnic identity exploration and resolution. J Res Adolesc. 2023;33(1):24-42. doi:10.1111/jora.12760
  • Demidenko MI, Kelly DP, Hardi FA,…Keating DP. Mediating effect of pubertal stages on the family environment and neurodevelopment: an open-data replication and multiverse analysis of an ABCD Study®. Neuroimage Rep. 2022;2(4):100133. doi:10.1016/j.ynirp.2022.100133
  • Demidenko MI, Huntley ED, Weigard AS, Keating DP, Beltz AM. Neural heterogeneity underlying late adolescent motivational processing is linked to individual differences in behavioral sensation seeking. J Neurosci Res. 2022;100(3):762-779. doi:10.1002/jnr.25005
  • Constante K, Huntley ED, Si Y, Schillinger E, Wagner C, Keating DP. Conceptualizing protective family context and its effect on substance use: comparisons across diverse ethnic-racial youth. Subst Abus. 2021;42(4):796-805. doi:10.1080/08897077.2020.1856289
  • Demidenko MI, Ip KI, Kelly DP, Constante K, Goetschius LG, Keating DP. Ecological stress, amygdala reactivity, and internalizing symptoms in preadolescence: is parenting a buffer? Cortex. 2021;140:128-144. doi:10.1016/j.cortex.2021.02.032
  • Demidenko MI, Weigard AS, Ganesan K,…Keating DP. Interactions between methodological and interindividual variability: how Monetary Incentive Delay (MID) task contrast maps vary and impact associations with behavior. Brain Behav. 2021;11(5):e02093. doi:10.1002/brb3.2093
  • Demidenko MI, Huntley ED, Jahn A, Thomason ME, Monk CS, Keating DP. Cortical and subcortical response to the anticipation of reward in high and average/low risk-taking adolescents. Dev Cogn Neurosci. 2020;44:100798. doi:10.1016/j.dcn.2020.100798
  • Huntley ED, Marusak HA, Berman SE,…Keating DP, et al. Adolescent substance use and functional connectivity between the ventral striatum and hippocampus. Behav Brain Res. 2020;390:112678. doi:10.1016/j.bbr.2020.112678